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Desensitization against blood group antibodies is relatively easy and has little impact on graft survival, whereas anti-HLA antibodies are difficult to desensitize and have a negative impact on graft survival due to the increased risk of AMR. One possible cause of this is accommodation, which is defined as the absence of AMR despite the presence of antibody production in the body. However, the molecular mechanism of accommodation to anti-blood group and anti-HLA antibodies remains unclear.
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“Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities.
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H. Leon Pachter Chair
Professor of Surgery
Director of the NYU Langone Transplant Institute
New York, USA
Robert A. Montgomery, MD, DPhil, FACS, is the H. Leon Pachter Chair and Professor of Surgery, Director of the NYU Langone Transplant Institute. He received his Doctor of Medicine with Honor from the University of Rochester School of Medicine. He received his Doctor of Philosophy from Balliol College, The University of Oxford, England in Molecular Immunology. Montgomery completed his general surgical training, multi-organ transplantation fellowship, and postdoctoral fellowship in Human Molecular Genetics at Johns Hopkins. For over a decade he served as the Chief of Transplant Surgery and the Director of the Comprehensive Transplant Center at Johns Hopkins.
Dr. Montgomery was part of the team that developed the laparoscopic procedure for live kidney donation, a procedure that has become the standard throughout the world. He and the Hopkins team conceived the idea of the Domino Paired Donation (kidney swaps), the Hopkins protocol for desensitization of incompatible kidney transplant patients, and performed the first chain of transplants started by an altruistic donor. He led the team that performed the first 2-way domino paired donation, 3-way paired donation, 3-way domino paired donation, 4-way paired donation, 4-way domino paired donation, 5-way domino paired donation, 6-way domino paired donation, 8-way multi-institutional domino paired donation, and co-led the first 10-way open chain. He is credited in the 2010 Guinness Book of World Records with the most kidney transplants performed in 1 day. He is considered a world expert on kidney transplantation for highly sensitized and ABO incompatible patients and is referred the most complex patients from around the globe.
Dr. Montgomery has had clinical and basic science research supported by the NIH throughout his career. His academic interests include HLA sensitization, tolerance protocols including simultaneous solid organ and bone marrow transplantation, and xenotransplantation. He has received important awards and distinctions including a Fulbright Scholarship and a Thomas J. Watson Fellowship and memberships in the Phi Beta Kappa and Alpha Omega Alpha academic honor societies. He has been awarded multiple scholarships from The American College of Surgeons and The American Society of Transplant Surgeons. The National Kidney Foundation of Maryland has recognized his contributions to the field of transplantation with the Champion of Hope Award, the National Kidney Registry with the Terasaki Medical Innovation Award and The Greater New York Hospital Association with the Profile in Courage Award. In 2018, he became a recipient of a heart transplant from a Hepatitis C positive donor and has worked to try to promote this practice throughout the world.
Graduate School of Biomedical and Health Sciences,
Welcome and introduction by the Chairs
Presentation: Different approach in immunosuppression to ABO and HLA-incompatible organ Transplantation, Robert Montgomery, USA
Presentation: Molecular mechanisms of accommodation in ABO- and HLA-incompatible organ Transplantation, Hideki Ohdan, Japan
Interactive panel discussion with audience participation led by the Chairs
Masterclass closing remarks