HLA matching plays of vital importance in transplantation because mismatches of HLA alleles possibly evoke both cellular and antibody-mediated rejection. As such, it would be ideally plausible if we can only transplant organs with zero HLA mismatch. However, with a shortage of organs, the use of mismatched organs became essential. The introduction of potent immunosuppressive agents for both induction and maintenance therapy helped controlling cellular rejection but not humoral mediated rejection (AMR), which is strongly correlated with donor-specific anti-HLA antibodies (DSA), resulting in a poor outcome. We have Dr. Zafar with vast experience in transplanting living related patients with the best HLA matching and Dr. Asker, who will present the impact of HLA in the diseased transplant program.
Presentation:Outcome with HLA matching results in deceased renal transplant, Medhat Askar, USA
Live Q&A with Medhat Askar, USA
Presentation: Outcome with HLA matching in living renal transplant, Mirza Naqi Zafar, Pakistan
Live Q&A with Mirza Naqi Zafar, Pakistan
Masterclass closing remarks