Description:
Machine perfusion has the potential to revolutionize transplantation by expanding the donor pool, enhancing the coordination of donation and transplantation programs, allowing the transportation of organs across long distances, and even pre-treating donor organs. This masterclass will provide an overview of the current state of the field and future outlook.
Learning Objectives:
- Understand the various technologies and differences between machine perfusion devices
- Review the evidence for their use and potential to enhance outcomes
- Consider the settings in which machine perfusion may be beneficial
How important is the temperature in organ transport?
Peter Friend
Professor of Transplantation
Consultant Transplant and HPB Surgeon
Director Oxford Transplant Centre
University of Oxford, Medical Sciences Division
Oxford, UK
Prof. Friend studied medicine at Cambridge and St Thomas’s Hospital and after qualifying trained as a surgeon in London and Cambridge before undertaking a period of research at the University of Cambridge under the supervision of Professor Sir Roy Calne.
In 1988 he was appointed Visiting Assistant Professor of Surgery at Indiana University Medical Center, USA, where he was responsible for initiating a programme of liver transplantation. Prof. Friend returned to the UK in 1989 to take up the post of University Lecturer (honorary consultant) in the University Department of Surgery at Cambridge. He was the Clinical Director of the Cambridge Transplant Unit and also a Fellow and Director of Studies in Medicine at Magdalene College, Cambridge. He was appointed to his current post in 1999.
Prof. Friend experimental interest is in the application of isolated perfusion of the liver to a number of therapeutic areas. In particular, perfusion of the liver with oxygenated blood at normal body temperature can allow recovery from damage, extended preservation for transplantation and organ specific delivery of therapy.
Clinical research studies include small scale pilot studies of novel immunosuppressive strategies and the organisation of a multi centre national trial.
How important is oxygen in organ transport?
Henri Leuvenink
Head of Transplantation Section, Surgical Research Lab
Program Coordinator Groningen Institute for Transplantation
University Medical Centre Groningen
Groningen, The Netherlands
Professor Henri Leuvenink is head of the section transplantation of the surgical research lab, and program coordinator Groningen institute for transplantation at the University Medical Centre Groningen in Groningen, the Netherlands. He is also a visiting professor at the University of Oxford and Aarhus. His main research interests are organ preservation, machine perfusion, and transplantation. Professor Leuvenink is a founding member of the European Consortium on Organ Preservation (COPE) and former chair of the basic science committee of the European Society of Organ Transplantation, the machine perfusion implementation committee Dutch transplant society, and several other research and basic science committees. He has wide experience in the organization and execution of multi-center studies in transplantation (Machine perfusion trial, NEJM 2009 and the COMPARE trial (Lancet 2020).
